Nyckelord
bilirubin induced neurologic dysfunction
hyperbilirubinemia
bilirubin encephalopathy
newborn jaundice
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Abstract
Jaundice is a common and often benign problem in neonates. In the first week of life around 60% of term neonates and 80% of preterm neonates develop jaundice. For yet unidentified reasons, bilirubin predominantly accumulates in the deep nuclei of the brain upon severe hyperbilirubinemia.
Referenser
Correspondence: Tina M Slusher Division of Global Health, Pediatric Intensive Care Faculty, Hennepin County Medical Center, University of Minnesota, 701 Park Ave, G7, Minneapolis, M
Division of Neuropathology, University of Alberta and Stollery Children’s Hospital, Edmonton, AB T6G 2B7, Canada; vanlande@ualberta.ca
Olusanya BO, Osibanjo FB, Mabogunje CA, Slusher TM, Olowe SA. The burden and management of neonatal jaundice in Nigeria: a scoping review of the literature. Niger J Clin Pract. 2016;19(1):1–17.
Bhutani VK, Zipursky A, Blencowe H, et al. Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels. Pediatr Res. 2013;74 .Suppl 1:86–100.
Burke BL, Robbins JM, Bird TM, Hobbs CA, Nesmith C, Tilford JM. Trends in hospitalizations for neonatal jaundice and kernicterus in the United States, 1988–2005. Pediatrics. 2009;123(2):524–532.
Ebbesen F, Andersson C, Verder H, et al. Extreme hyperbilirubinaemiain term and near-term infants in Denmark. Acta Paediatr.2005;94(1):59–64.
Bhutani VK, Johnson L. Kernicterus in the 21st century: frequently asked questions. J Perinatol. 2009;29 Suppl 1:S20–S24.
Brooks JC, Fisher-Owens SA, Wu YW, Strauss DJ, Newman TB. Evidence suggests there was not a “resurgence” of kernicterus in the 1990s. Pediatrics. 2011;127(4):672–679.
Ebbesen F, Bjerre JV, Vandborg PK. Relation between serum bilirubin levels ≥450 μmol/L and bilirubin encephalopathy; a Danish populationbased study. Acta Paediatr. 2012;101(4):384–389.
Sgro M, Campbell DM, Kandasamy S, Shah V. Incidence of chronic bilirubin encephalopathy in Canada, 2007–2008. Pediatrics. 2012;130(4): e886–e890.